If you mean the default Members list, you can create your own search block (based on the Search Block) and add or remove hidden fields in it to specify what sections are searched:
<form style="margin: 0px;" method="post" action="modules.php">
<input value="Search" name="name" type="hidden">
<input value="index" name="file" type="hidden">
<input value="modload" name="op" type="hidden">
<input value="search" name="action" type="hidden">
<input value="1" name="overview" type="hidden">
<input value="1" name="active_weblinks" type="hidden">
<input value="1" name="active_stories" type="hidden">
<input value="1" name="active_sections" type="hidden">
<input value="1" name="active_reviews" type="hidden">
<input value="1" name="active_faqs" type="hidden">
<input value="1" name="active_downloads" type="hidden">
<input value="1" name="active_users" type="hidden">
<input value="OR" name="bool" type="hidden">
<input value="" name="stories_cat" type="hidden">
<input value="" name="stories_topics" type="hidden">
<input style="font-size: 10px;" value="" type="text" name="q" class="pn-text">
<input style="font-size: 10px;" value="go!" name="Submit" type="submit">
</form>
You can take out the hidden form elements you don't need (the "active_*" ones)...
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